Development and evaluation of floating microspheres of verapamil hydrochloride
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چکیده
منابع مشابه
Formulation and Evaluation of Floating beads of Verapamil hydrochloride
To develop a multi-unit gastroretentive sustained release dosage form of a water-soluble drug, Verapamil hydrochloride, from a completely aqueous environment. avoiding the use of any organic solvent, thus releasing the drug for a prolonged duration of time. Emulsion gelation technique was used to prepare emulsion gel beads using sodium alginate as the polymer. The gel beads containing oil was p...
متن کاملFormulation Development and in Vitro Evaluation of Gastro Retentive Floating Microspheres of Verapamil Hydrocloride
Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids and thus it remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Verapamil HCL is calcium channel blocker drug with short elimination half-life 2.8-7.4 hours Floating microspheres of Verapamil HCL wer...
متن کاملDevelopment and Evaluation of Floating Microspheres of Curcumin
Purpose: To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence time and increased drug bioavailability. Methods: Floating microsphere were prepared by emulsion solvent diffusion method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:...
متن کاملCefpodoxime Proxetil Floating Microspheres: Formulation and In Vitro Evaluation
The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...
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ژورنال
عنوان ژورنال: Revista Brasileira de Ciências Farmacêuticas
سال: 2007
ISSN: 1516-9332
DOI: 10.1590/s1516-93322007000400005